Cell — The Fundamental Unit of Life
"The cell is the basic unit of LIFE. From bacteria to blue whales — everything alive is made of cells."
1. Discovery of the Cell
Robert Hooke (1665) : Observed thin slices of CORK under a microscope. Saw tiny compartments like 'little rooms' and called them CELLS. 'Hooke saw DEAD cells — the cell walls of cork. He did NOT see living cells.' Anton van Leeuwenhoek (1674) : First to observe LIVING cells (bacteria, protozoa, sperm) using hand-ground lenses. Robert Brown (1831) : Discovered the NUCLEUS in orchid cells.
2. Cell Theory (Schleiden, Schwann, Virchow)
- All living organisms are composed of CELLS and CELL PRODUCTS (Schleiden, 1838 — botanist; Schwann, 1839 — zoologist). 2. The cell is the BASIC STRUCTURAL and FUNCTIONAL UNIT of all organisms. 3. All cells arise from PRE-EXISTING CELLS (Rudolf Virchow, 1855: 'Omnis cellula e cellula'). Exception: Viruses are NOT cellular — they are acellular infectious particles at the border of living/non-living.
3. Prokaryotic vs Eukaryotic Cells
| Feature | Prokaryotic | Eukaryotic |
|---|---|---|
| Nucleus | NO nuclear membrane. Nucleoid. | TRUE nucleus, double membrane. |
| Membrane-bound organelles | ABSENT | Present (mitochondria, ER, Golgi, lysosomes) |
| Ribosomes | 70S | 80S |
| Size | 1-10 μm | 10-100 μm |
| Cell division | Binary fission | Mitosis and Meiosis |
| Examples | Bacteria, Cyanobacteria, Mycoplasma | Plants, Animals, Fungi, Protists |
The Endosymbiotic Theory (Lynn Margulis, 1967)
Mitochondria and chloroplasts were once FREE-LIVING prokaryotes. A larger prokaryote ENGULFED them — and instead of digesting them, kept them as symbionts. Evidence: Both have their OWN circular DNA (like bacteria). Both have 70S ribosomes. Both divide by BINARY FISSION. Both have DOUBLE membranes. 'This is one of the most BEAUTIFUL theories in biology — it explains how complex eukaryotic cells evolved from simple prokaryotic ancestors.'
4. Plant Cell vs Animal Cell
| Feature | Plant Cell | Animal Cell |
|---|---|---|
| Cell Wall (cellulose) | Present | Absent |
| Chloroplasts | Present | Absent |
| Vacuole | LARGE central | Small, temporary |
| Centrioles | Absent | Present |
| Shape | Usually REGULAR | IRREGULAR |
5. Cell Organelles — Structure and Function
Nucleus — Control Centre
Double membrane with PORES. Contains CHROMATIN (DNA + proteins). Contains NUCLEOLUS (rRNA synthesis). 'Red blood cells in mammals lose their nucleus to carry more haemoglobin.'
Mitochondria — Powerhouse
Double membrane. Inner folds = CRISTAE (increase surface area). Site of AEROBIC RESPIRATION: glucose + O₂ → CO₂ + H₂O + ATP. Cells needing MORE energy have MANY more mitochondria.
Endoplasmic Reticulum (ER)
Rough ER (with ribosomes): Protein synthesis. Smooth ER: Lipid synthesis. Detoxification.
Ribosomes — Protein Factories
80S in eukaryotes. 70S in prokaryotes, mitochondria, chloroplasts.
Golgi Apparatus
Stack of cisternae. Modifies, packages, and ships proteins. Forms LYSOSOMES.
Lysosomes — Suicide Bags
Contain powerful digestive enzymes (acid hydrolases). Digest foreign material, worn-out organelles. During METAMORPHOSIS (tadpole → frog), lysosomes digest the tail.
Chloroplasts (Plant Only)
Double membrane. Internal thylakoids (GRANA) contain chlorophyll. STROMA = site of dark reaction/Calvin cycle. Own DNA + 70S ribosomes.
Vacuoles
Plants: LARGE central vacuole — maintains TURGOR pressure. In Amoeba: CONTRACTILE vacuole (osmoregulation). FOOD vacuole (digestion).
6. Osmosis and Diffusion
Diffusion: Movement from HIGH to LOW concentration. Passive (no energy). Osmosis: Diffusion of WATER across a SELECTIVELY PERMEABLE membrane. Hypotonic (lower solute outside): Water ENTERS → cell SWELLS. Isotonic (same): No net movement. Hypertonic (higher solute outside): Water LEAVES → cell SHRINKS.
Plasmolysis: When a plant cell is in HYPERTONIC solution → water leaves → cell membrane pulls away from cell wall. 'This is why plants WILT when not watered — the cells lose turgor.'
7. Cell Division — An Introduction
Mitosis: Produces 2 DIPLOID (2n) daughter cells — genetically IDENTICAL to parent. For GROWTH and REPAIR. Meiosis: Produces 4 HAPLOID (n) cells — genetically DIFFERENT. For GAMETE formation (sperm/egg). 'Mitosis occurs in SOMATIC (body) cells. Meiosis occurs only in GERM cells (gonads).'
8. Common Mistakes
- 'All cells have a nucleus' — Mature RBCs have NO nucleus. Prokaryotes have nucleoid (no membrane).
- 'Mitochondria and chloroplasts are like other organelles' — They have OWN DNA + ribosomes. SEMI-AUTONOMOUS.
- 'Cell wall = cell membrane' — Cell WALL (cellulose, outer, rigid). Cell MEMBRANE (inner, selectively permeable). Plant cells have BOTH.
9. AP SSC Exam Focus
| Topic | Marks |
|---|---|
| Prokaryotic vs Eukaryotic | 3-4 |
| Plant vs Animal cell | 3-4 |
| Organelles and functions | 4-5 |
| Osmosis | 3-4 |
| Endosymbiotic theory | 2-3 |
Key Diagrams
Draw and label: TYPICAL PLANT CELL and ANIMAL CELL with all organelles.
Cell Organelles — Quick Reference Table
| Organelle | Membrane | Key Feature |
|---|---|---|
| Nucleus | Double + pores | Contains DNA. Control centre. |
| Mitochondria | Double (inner folded → cristae) | ATP production. Own DNA + 70S ribosomes. |
| Rough ER | Single, with ribosomes | Protein synthesis and transport |
| Smooth ER | Single, no ribosomes | Lipid synthesis. Detoxification. |
| Golgi | Single (stacked cisternae) | Packages and ships proteins. Forms lysosomes. |
| Lysosomes | Single | Digestive enzymes (pH~5). Suicide bags. |
| Chloroplasts | Double, internal thylakoids (grana) | Photosynthesis. Own DNA + 70S ribosomes. |
| Vacuole | Single (tonoplast) | Storage. Turgor (plants). Osmoregulation. |
Quick Memory: 'NUMEG CLV'
Nucleus, Mitochondria, ER, Golgi, Chloroplasts, Lysosomes, Vacuoles — the 7 key organelles every AP student must know.
